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Showing posts with label Cannabis. Show all posts
Showing posts with label Cannabis. Show all posts

Monday, December 9, 2013

Prohibited Research?

From Scientific American:

Imagine being an astronomer in a world where the telescope was banned. This effectively happened in the 1600s when, for over 100 years, the Catholic Church prohibited access to knowledge of the heavens in a vain attempt to stop scientists proving that the earth was not the center of the universe.  ‘Surely similar censorship could never happen today,’ I hear you say—but it does in relation to the use of drugs to study the brain.  Scientists and doctors are banned from studying many hundreds of drugs because of outdated United Nations charters dating back to the 1960s and 1970s.

Read more:
The Potential of LSD, Heroin, Marijuana and Other Controlled Substances in Brain Research

SuccubaSuprema writes:


The "guardians" of society (sometimes self-appointed, seldom qualified) have not uncommonly been biased by personal dogmatic beliefs, whether those beliefs were religious, political, economic, or something else.  In the case of seventeenth-century astronomy, the bias of the "guardians" was religious, a biblical literalism which, however, was not consistent with the Tradition of the Church -- but then again, that Tradition itself is hardly self-referentially consistent, contradicting itself on any number of points.  Indeed, as I have mentioned in previous posts here, a worldview colors one's perception of everything, and thus can result in distorted perceptions.  In the case of substance research, several different beliefs have resulted in such skewed perspectives.  In some cases, the culprit is a political viewpoint, in particular as relates to Philosophy of Law ("crime and punishment" and "protection of society" from perceived threats), without much regard for, or consideration of, the contentions of the medical community that addiction and dependence are medical situations, rather than (inherently) criminal.  In other cases, a political viewpoint is again involved, but in a sort of "us versus them" mentality, such that the "guardians" arrive at their conclusions based on opposition to an alternate political viewpoint.  In still other cases, economic viewpoints are involved, sometimes with vested interests (since Cannabis, for example, is an herb which can be grown almost anywhere, in widely varying conditions, its manufacture, distribution, and use cannot be effectively controlled -- and it cannot be patented, and thus, profits from Cannabis cannot be reliably restricted to the pharmaceutical industry, which has numerous less effective and potentially more harmful substances from which it wishes to continue to profit, regardless of the consequences for patients).  In yet other cases, the bias is again due to a religious viewpoint, whether that be the anti-intellectualism and epistemophobia (fear of knowledge) which is so typical of religious fundamentalists, or a belief that the distribution and use of such substances are somehow contrary to the will of the divine and thus must be prohibited (disregarding any lack of justification for such prohibition on the basis of separation of church and state, ignoring the failures of past efforts at prohibition, and, in the specific case of Christianity, blatantly defying teachings of the religion itself, in particular as regards such teachings as are found in the fifth, sixth, and seventh chapters of the gospel of Matthew and the fourteenth chapter of the epistle to the Romans).

In still yet other cases, addiction and/or dependence, or even a perspective based on an idealized understanding of the psychedelic movement (which may itself have religious dimensions, as suggested by, for example, the writings of Carlos Castaneda, and/or claims made by Dr. Timothy Leary), must be acknowledged as capable of biasing conclusions, with those who wish to have license to use such substances themselves basing their conclusions on that wish.

In spite of the latter possibility, the potential for increased knowledge (both neuroscientific/psychiatric and otherwise medical) from research into these substances is far more relevant and important than the fears of those who have embraced ignorance, superstition, irrationality, and prejudice.


Tuesday, September 3, 2013

How Many People Have Died from a Marijuana Overdose?

The Huffington Post has some details:
Here Are All The People Who Have Died From A Marijuana Overdose

The answer is, of course, ZERO.  A big, fat ZERO!

In fact, long before a person could die from Cannabis poisoning via smoking, they would be dead from Carbon Monoxide poisoning.

Now, how many innocent people have been victims of "the War on Drugs"?  I'm not sure there's any official answer, but the slide show at the bottom of the "HuffPo" article discusses a few of them.  Figures from Mexico's "War on Drugs" are available (as noted below with reference to the WSJ).

How many violations of the Bill of Rights have occurred as a result of "the War on Drugs"?  I doubt there are any hard figures on this, but the number would obviously exceed the number of those innocents who died as a result of "the War on Drugs."

How many violent offenders have been released early due to Federal laws requiring "mandatory minimum sentences" for any drug crime, including non-violent possession and use?  The WSJ has some figures on numbers of people incarcerated in the US, connected to "the War on Drugs."

How much money is spent annually on "the War on Drugs"?  Again, the WSJ provides an estimate of this.

From The Wall Street Journal:

Total current spending is estimated at over $40 billion a year. ...
The total number of persons incarcerated in state and federal prisons in the U.S. has grown from 330,000 in 1980 to about 1.6 million today. Much of the increase in this population is directly due to the war on drugs and the severe punishment for persons convicted of drug trafficking. About 50% of the inmates in federal prisons and 20% of those in state prisons have been convicted of either selling or using drugs. The many minor drug traffickers and drug users who spend time in jail find fewer opportunities for legal employment after they get out of prison, and they develop better skills at criminal activities. ...

Mexico offers a well-documented example of some of the costs involved in drug wars. Probably more than 50,000 people have died since Mexico's antidrug campaign started in 2006. ...
Read more:  Have We Lost the War on Drugs?


Most Likely States to Legalize Cannabis Next

From The Huffington Post:

Attorney General Eric Holder gave a green light on Thursday to two states whose efforts to legalize marijuana had been locked in by legal uncertainty for more than nine months. With that announcement, Colorado and Washington -- both of which passed pro-pot initiatives at the polls last November -- can now proceed with establishing a framework for the taxation and regulation of legal weed for adults.

Read more:  These States Are Most Likely To Legalize Pot Next

Monday, August 26, 2013

Five Reasons Cops Want to Legalize Marijuana

Five Reasons Cops Want to Legalize Marijuana

More and more police officers are realizing the War on Drugs is a mistake


All of these are very compelling reasons to legalize Cannabis.  Let's also remember the medical value of the herb, as I reported here in an earlier post.  And that post's contents are just the tip of the iceberg regarding the medical benefits of Cannabis.  Remember, Clarence Thomas is not a medical expert.

Friday, August 16, 2013

“Please don’t let my daughter die, Governor.”

‘Please don’t let my daughter die’: Father begs Chris Christie to legalize medical marijuana [VIDEO]

An aggrieved father confronted New Jersey Gov. Chris Christie during a campaign stop on Wednesday, begging the Republican to sign into law a bill that would provide easier access to medical marijuana for children, CBS New York reports.

Brian Wilson’s 2-year-old daughter Vivian is diagnosed with Dravet Syndrome, a rare and potentially lethal form of epilepsy. She wears glasses to avoid having light trigger seizures and has stopped breathing twice during epileptic episodes, her parents said.

Chris Christie Confronted By Dad Over Medical Marijuana For Kids [Video]

Last month, Christie expressed reservations about the bill during a radio program. “I’m concerned about expanding the program. And I want to make sure that if we do it, we do it in a way that is helpful to children, does not reduce any of the requirements of the program; to make sure this does not go down a slippery slope of broadening the program and making it easier (for unqualified people) to get marijuana.”

Non Causa Pro Causa is a type of the logical fallacy known as "Slippery Slope."  A logical fallacy is an incorrect inference form, or, more prosaically, an example of faulty reasoning.  We've seen this before from the Right Wing (and in particular, "the Religious Right"), for example in connection with Marriage Equality (in which they not only commit the fallacy of Non Causa Pro Causa, but also the fallacy of Argumentum ad Hominem, specifically in the Abusive ad Hominem variety, by essentially equating Gay Marriage with pedophilia, bestality, etc).  Fallacy is in fact all too common from politicians of every party and ideology, but an ideology which glorifies ignorance, prejudice, superstition and irrationality, such as does the Religious Right, is obviously more likely to make use of erroneous reasoning.

But, Donna Giovanna, isn't there something else the little girl can take?

No, as seen in this article (and blatantly stated in the CNN broadcast today):
Chris Christie expected to announce decision on medical marijuana bill

Brian Wilson's 2-year-old daughter, Vivian, suffers a version of epilepsy called Dravet syndrome. Normal epilepsy medications have so far failed to work for Vivian, and her family believes a certain type of medical marijuana -- one with high levels of cannabidiol, or CBD -- may be able to help. High-CBD strains of marijuana have helped other patients with Dravet Syndrome.

You'll note in the videos that Christie believes that his office entitles him to "make these decisions."  Au contraire.  The Ninth and Tenth Amendments to the US Constitution say otherwise.

But just who is this Governor Chris Christie, anyway?

Chris Christie is the favorite for the GOP's super-rich:  The GOP wants the New Jersey governor to save the party from Sen. Rand Paul's libertarian wing

The donor class that wanted Christie, settled for Romney, and wants Christie again needs a candidate who’ll slash at regulation in office and come off patriotic (and pro-Israel) enough to actually get into office. ...

Every week there’s another reminder that the GOP’s libertarian wing hasn’t truly overcome the Bush wing. Back in Aspen, Christie gave them more fresh evidence. “President Obama has done nothing to change the policies of the Bush administration in the war on terrorism,” he said. “I mean practically nothing. You know why? Because they work.”
Violations of the Bill of Rights do NOT work.  They instead promote the causes of hatred of "our freedoms" which George W. Bush alleged was the motivation of the terrorists.


BREAKING NEWS:
From CNN:  "New Jersey Gov. Chris Christie supports easing access to medical marijuana for sick children."
... but issues a qualified veto of the bill.

I'll update this later when a full article will hopefully be ready from a news source, but the quoted bit above can currently be found at the top of the same CNN article linked above;  it does not yet mention the qualified veto, which was discussed on CNN moments ago.

UPDATE:
New Jersey Gov Christie to ease access to medical marijuana for children

Gov. Chris Christie has agreed to give chronically ill children easier access to medical marijuana.

However, the governor conditionally vetoed a bill on the issue because it goes further than he was willing to go.

America, is this the person you want to be the President?  I'll be voting against him myself.

Tuesday, August 13, 2013

Cannabis Fights Cancer

The National Institutes of Health support this claim:
National Cancer Institute at the National Institutes of Health

A portion of this page reads as follows:

Have any preclinical (laboratory or animal) studies been conducted using Cannabis or cannabinoids?
Preclinical studies of cannabinoids have investigated the following activities:
Antitumor activity
  • Studies in mice and rats have shown that cannabinoids may inhibit tumor growth by causing cell death, blocking cell growth, and blocking the development of blood vessels needed by tumors to grow. Laboratory and animal studies have shown that cannabinoids may be able to kill cancer cells while protecting normal cells.
  • A study in mice showed that cannabinoids may protect against inflammation of the colon and may have potential in reducing the risk of colon cancer, and possibly in its treatment.
  • A laboratory study of delta-9-THC in hepatocellular carcinoma (liver cancer) cells showed that it damaged or killed the cancer cells. The same study of delta-9-THC in mouse models of liver cancer showed that it had antitumor effects. Delta-9-THC has been shown to cause these effects by acting on molecules that may also be found in non-small cell lung cancer cells and breast cancer cells.
  • A laboratory study of cannabidiol in estrogen receptor positive and estrogen receptor negative breast cancer cells showed that it caused cancer cell death while having little effect on normal breast cells.
  • A laboratory study of cannabidiol in human glioma cells showed that when given along with chemotherapy, cannabidiol may make chemotherapy more effective and increase cancer cell death without harming normal cells.
Stimulating appetite
  • Many animal studies have shown that delta-9-THC and other cannabinoids stimulate appetite and can increase food intake.
Pain relief
  • Cannabinoid receptors (molecules that bind cannabinoids) have been studied in the brain, spinal cord, and nerve endings throughout the body to understand their roles in pain relief.
  • Cannabinoids have been studied for anti-inflammatory effects that may play a role in pain relief.
Have any clinical trials (research studies with people) of Cannabis or cannabinoid use by cancer patients been conducted?
No clinical trials of Cannabis as a treatment for cancer in humans have been found in the CAM on PubMed database maintained by the National Institutes of Health.
Cannabis and cannabinoids have been studied in clinical trials for ways to manage side effects of cancer and cancer therapies, including the following:
Nausea and vomiting
  • Delta-9-THC taken by mouth: Two cannabinoid drugs approved in the United States are available under the names dronabinol and nabilone. Both dronabinol and nabilone are approved by the Food and Drug Administration (FDA) for the treatment of chemotherapy-related nausea and vomiting in patients who have not responded to standard therapy. Many clinical trials have shown that both dronabinol and nabilone worked as well as or better than some of the weaker FDA-approved drugs to relieve nausea and vomiting. Newer drugs given for chemotherapy-related nausea have not been directly compared with Cannabis or cannabinoids in cancer patients.
  • Inhaled Cannabis: Three small trials have studied inhaled Cannabis for the treatment of chemotherapy-related nausea and vomiting. Various study methods and chemotherapy agents were used with mixed results. There is not enough information to interpret these findings.
Stimulating appetite
  • Delta-9-THC taken by mouth: A clinical trial compared delta-9-THC (dronabinol) and a standard drug (megestrol) in patients with advanced cancer and loss of appetite. Results showed that delta-9-THC was not as effective in increasing appetite or weight gain in advanced cancer patients compared with standard therapy. However, a clinical trial of patients with HIV/AIDS and weight loss found that those who took delta-9-THC had increased appetite and stopped losing weight compared with patients who took a placebo.
  • Inhaled Cannabis: There are no published studies of the effect of inhaled Cannabis on cancer patients with loss of appetite. Studies of healthy people who inhaled Cannabis showed that they consumed more calories, especially high-fat and sweet snacks.
Pain relief
  • Combining cannabinoids with opioids: In a small study of 21 patients with chronic pain, vaporized Cannabis was added to slow-release oxycodone or morphine and given for five days. Results showed that combining vaporized Cannabis with morphine relieved pain better than morphine alone, while combining vaporized Cannabis with oxycodone did not produce significantly greater pain relief. These findings should be tested in further studies.
  • Delta-9-THC taken by mouth: Two small clinical trials of oral delta-9-THC showed that it relieved cancer pain. In the first study, patients had good pain relief as well as relief of nausea and vomiting and better appetite. A second study showed that delta-9-THC could be given in doses that gave pain relief comparable to codeine. Higher doses of delta-9-THC were found to be more sedating than codeine. An observational study of nabilone also showed that it relieved cancer pain along with nausea, anxiety, and distress when compared with no treatment. Neither dronabinol nor nabilone is approved by the FDA for pain management.
  • Whole Cannabis plant extract medicine: A study of a whole-plant extract of Cannabis that contained specific amounts of cannabinoids, which was sprayed under the tongue, found it was effective in patients with advanced cancer whose pain was not relieved by strong opioids alone. This treatment was studied using different doses in a randomized, placebo-controlled clinical trial of cancer patients with chronic pain not controlled by opioids. Patients who received the lower doses of cannabinoid spray showed markedly better pain control and less sleep loss compared with patients who received a placebo. Adverse side effects depended on the dose received. Only patients in the high-dose group had adverse side effects that made the treatment less beneficial than the placebo. Some patients using the cannabinoid spray were followed in a long-term study. Results showed that, for some patients, control of their cancer-related pain continued without needing higher doses of spray or higher doses of their other pain medicines.
  • Inhaled Cannabis: Various clinical trials have shown benefits of inhaled Cannabis compared with placebo in relieving neuropathic pain. These include a study of inhaled Cannabis in patients with HIV -related peripheral neuropathy. Results found better pain control in the Cannabis group than in the placebo group. Another study involved patients with various kinds of chronic pain that was not relieved by other pain medicines. Results showed that those treated with either low-dose or medium-dose inhaled Cannabis had improved pain relief at both doses compared to patients treated with a placebo. Side effects of the inhaled Cannabis were minor. To date, no clinical trials have studied cannabinoids in the treatment of chemotherapy-related neuropathy in patients with cancer.
Anxiety and sleep
  • Inhaled Cannabis: A small case series found that patients who inhaled marijuana had improved mood, improved sense of well-being, and less anxiety.
  • Whole Cannabis plant extract spray: A trial of a whole-plant extract of Cannabis that contained specific amounts of cannabinoids, which was sprayed under the tongue, found that patients had improved sleep quality.



Can we please pull our heads out of our butts and legalize Medical Cannabis now?

Thanks.